Zhang, Y., Huang, Y., Zhang,
P., Gao, X., Gibbs, R.B., and Li, S. (2012) Incorporation
of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple
cancer cells, International
Journal of Nanomedicine, In Press
Cai, L., Gibbs, R.B., Johnson, D.A. (2012)
Recognition of novel objects and their location in rats with selective
cholinergic lesions of the medial septum. Neuroscience Letters, 506(2):
261-265. PMID: 22119001
Gibbs, R.B., Chipman, A.M.,
Hammond, R. and Nelson, D. (2011) Galanthamine Plus Estradiol Treatment
Enhances Cognitive Performance in Aged Ovariectomized Rats, Horm.
& Behav.60:607-616. doi:10.1016/j.yhbeh.2011.08.010.PMID:
Gibbs, R.B., Chipman, A.M., and
Nelson, D. (2011) Donepezil Plus Estradiol Treatment
Enhances Learning and Delay-Dependent Memory Performance by Young
Ovariectomized Rats with Partial Loss of Septal Cholinergic Neurons,Horm. & Behav., 59(4): 503-11. DOI S0018-506X(11)00026-2 [pii] 10.1016/j.yhbeh.2011.01.011; PMID 3081392
Hammond, R.*, and Gibbs, R.B. (2011) GPR30 is
positioned to mediate estrogen effects on basal forebrain cholinergic neurons
and cognitive performance, Brain Res, 1379:53-60, doi:10.1016/j.brainres.2010.11.098;
Pokala, V.N., Witt-Enderby,
P.A., Gibbs, R.B., and Johnson, D.A. (2010). Selective septohippocampal
cholinergic lesioning in rat brain: Effects on muscarinic receptor function and
secretase enzyme activity. Curr.
Topics in Pharmacol.14: 73-78.
C.N. (2010) Evaluation of a Combined Therapeutic Regimen of
8-OH-DPAT and Environmental Enrichment After Experimental Traumatic Brain Injury,
J. Neurotrauma, 27:11, 2021-2032. DOI:
10.1089/neu.2010.1535; PMID 2978058
Hammond, R.*, Nelson, D., and Gibbs, R.B. (2010)
GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances
potassium-stimulated acetylcholine release in the hippocampus. Psychoneuroendocrinology, 36(2):182-192,
DOI: 10.1016/j.psyceuen.2010.07.007. PMID: 2994977
Gibbs, R.B. (2010) Does
Short-Term Estrogen Therapy Produce Lasting Benefits In Brain? Endocrinology,
Gibbs, R.B. (2010) Estrogen therapy
and cognition: A review of the cholinergic hypothesis, Endocrine Reviews 31(2):
Gibbs, R.B. (2009)
Animal Studies that Support Estrogen Effects on Cognitive Performance and the
Cholinergic Basis of the Critical Period Hypothesis, In: Hormones, Cognition
and Dementia: State of the Art and Emergent Therapeutic Strategies, E. Hogervorst, V. Henderson, R.B. Gibbs, and R. Brinton, Eds., Cambridge University†
Press, Cambridge, UK.
Ramaswamy, Gibbs, R.B., Plant, T.M.
(2009) Studies of the localization and action of kisspeptin
within the pituitary of the rhesus monkey (Macacamulatta), Journal of Neuroendocrinology, 10: 795-804.
Hammond, R., Mauk, R., Ninaci, D., Nelson, D.,
and Gibbs, R.B. (2009) Chronic treatment with estrogen receptor agonists
restores acquisition of a spatial memory task in young ovariectomized rats. Horm. & Behav., 56: 309-314.
Gibbs, R.B., Mauk, R., Nelson, D., Johnson, D.A. (2009) Donepezil
treatment restores the ability of estradiol to enhance cognitive performance in
aged rats: Evidence for the cholinergic basis of the critical period hypothesis.
Horm. & Behav., 56: 73-83. NIHMS123055, Publ.ID: YHBEH2819
Fitz, N., Gibbs,
R.B., and Johnson, D. (2008) Selective Lesions of Septal Cholinergic Neurons in
Rats Impairs Acquisition of a Delayed Matching to Position T-maze Task by
Delaying the Shift from a Response to a Place Strategy, Brain Res. Bull., 77: 356-360.
Ramaswamy, S., Guerriero,
K.A., Gibbs, R.B., Plant, T.M. (2008) Interactions between kisspeptin
and GnRH Neurons in the mediobasal hypothalamus of
the male rhesus monkey (Macacamulatta)
as revealed by double immunofluorescence and confocal microscopy.
Endocrinology, 149 (9): 4387-95.
Gibbs, R.B. and
Johnson, D.A. (2008) Sex specific effects of gonadectomy and hormone treatment
on acquisition of a 12-arm radial maze task by Sprague-Dawley rats. Endocrinology, 149(6): 3176-3183, PMC2408814.
Gibbs, R.B. (2007)
Estradiol enhances DMP acquisition via a mechanism not mediated by turning
strategy, but which requires basal forebrain cholinergic projections. Horm. & Behav., 52: 352-359, NIHMS 30086.
Gibbs, R.B. and
Johnson, D.A. (2007) Cholinergic lesions produce task-selective effects on
delayed matching to position and configural association learning related to
response pattern and strategy. Neurobiol. Learning and Memory, 88: 19-32, PMC1991294.
Lu, C., Walker,
W.H., Sun, J., Weisz, O.A., Gibbs, R.B., Witchel, S.F., Sperling, M.A.,
and Menon, R.K. (2006) Insulin-like peptide 6
(Insl6): Characterization of secretory status and post-translational
modification. Endocrinol. 147(12): 5611-5623.
Edwards, D., Lazar, N., Nelson, D., Talameh, J.
(2006) Effects of long-term hormone treatment and or tibolone
on monoamines and monoamine metabolites in the brains of ovariectomized, Cynomologous monkeys.†
J. Neuroendocrinol. 18:
Fitz, N, Gibbs,
R.B., and Johnson, D. (2006) Aversive stimulus attenuates impairment of
acquisition in a delayed match to position T-maze task caused by a selective
lesion of septohippocampal cholinergic
projections.† Brain Research Bulletin
Poloyac, S.M., Rohan,
L.C., Janjic, J.M., Gibbs, R.B., Kroboth,
P.D.K., Smith, R.B. (2005) GEAR-UP (Graduate Education And Research at the
University of Pittsburgh): A Program to Educate Students about Pharmaceutical
Research. American Journal of Pharmaceutical Education,
Gibbs, R.B. (2005) Testosterone and Estradiol Produce
Different Effects on Cognitive Performance in Male Rats.Horm. & Behav., 48: 268-277, PMC2376813.
Thomas, K., Sung, D-Y, Yang, J, Johnson, K., Thompson, W., Millette,
C., McCarrey, J., Breitberg,
A., Gibbs, R.B., Walker, W. (2005) Identification, characterization and
functional analysis of Sp1 transcript variants expressed in germ cells during
mouse spermatogenesis. Biol. of Reprod., 72: 898-907.
Gibbs, R.B., Gabor, R., Cox, T., Johnson, D.A. (2004) Raloxifene
enhances cholinergic function, but not learning, in ovariectomized rats. Psychoneuroendocrinol., 29:
Gibbs, R.B., Gabor, R. (2003) Estrogen and Cognition: Applying Preclinical
findings to Clinical Perspectives. J. Neurosci. Res.,
Rudick, C.N., Gibbs, R.B., and Woolley, C.S. (2003) A
role for the basal forebrain cholinergic system in estrogen-induced
disinhibition of hippocampal pyramidal cells. J. Neurosci., 23(11): 4479-4490.
Gibbs, R.B. (2003) Effects of aging and long-term hormone replacement on
cholinergic neurons in the medial septum and nucleus basalis magnocellularis of
ovariectomized rats. J. Neuroendocrinol., 15: 477-485.
Gabor, R., Nagle, R., Johnson, D.A., and Gibbs, R.B. (2003) Estrogen enhances
potassium-stimulated acetylcholine release in the rat hippocampus. Brain
Research, 962: 244-247.
Gibbs, R.B. (2002) Basal forebrain cholinergic neurons are necessary for
estrogen to enhance acquisition of a delayed matching to position T-maze task. Horm. & Behav., 42:245-257.
Gibbs, R.B., Nelson, D., Anthony, M.S., and Clarkson, T.B. (2002) Effects of
long-term hormone replacement and of tibolone on
choline acetyltransferase and acetylcholinesterase activities in the brains of
ovariectomized, cynomologous monkeys. Neuroscience,
Johnson, D.A., Zambon, N.J., and Gibbs, R.B. (2002)
Selective lesions of cholinergic neurons in the medial septum by 192
IgG-Saporin impairs learning of a delayed matching to position T-maze paradigm.
Brain Research, 943:132-141.
Gibbs, R.B. (2000) Effects of gonadal hormone replacement on
measures of basal forebrain cholinergic function.Neurosci., 101(4):931-938.
Aggarwal, P. and Gibbs, R.B. (2000) Estrogen
replacement does not prevent the loss of choline acetyltransferase positive cells
in the basal forebrain following either neurochemical or mechanical lesions.
Brain Research, 882:75-85.
Gibbs, R.B. (2000) Long-term treatment with estrogen and progesterone enhances
acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol. of Aging, 21: 107-116.
Gibbs, R.B. (1999) Estrogen replacement enhances acquisition of a spatial
memory task and reduces deficits associated with hippocampal muscarinic
receptor inhibition. Hormones & Behavior 36: 222-233.
Gibbs, R.B. (1999) Treatment with estrogen and progesterone affects relative
levels of brain-derived neurotrophic factor mRNA and protein in different
regions of the adult rat brain. Brain Research 844(1-2):
Gibbs, R.B., Aggarwal, P. (1998) Estrogen and basal
forebrain cholinergic neurons: Implications for brain aging and Alzheimer's
disease-related cognitive decline, Hormones & Behavior 34:98-111.
Gibbs, R.B., Burke, A.M., and Johnson, D.A. (1998) Estrogen replacement
attenuates effects of scopolamine and lorazepam on
memory acquisition and retention, Hormones & Behavior 34:112-125.
Gibbs, R.B. (1998) Impairment of basal forebrain cholinergic
neurons associated with aging and long-term hormone deprivation in rats, Exp.
Neurol. 151: 289-302.
Gibbs, R.B. (1998) Changes in relative levels of trkA and BDNF mRNA, but not
NGF mRNA, across the estrous cycle and in response to acute hormone
replacement, Brain Research 787: 259-268.
McCarthy, M.M., Besmer, H.R., Jacobs, S.C., Keidan, G.M.O., and Gibbs, R.B. (1997) Influence of
maternal grooming, sex and age on Fos
immunoreactivity in the preoptic area of neonatal rats: implications for sexual
differentiation, Dev. Neurosci. 19:
Gibbs, R.B. (1997) Effects of estrogen on basal forebrain cholinergic neurons
vary as a function of dose and duration of treatment, Brain Research 757:
Gibbs, R.B. and Martynowski, C. (1997) Nerve growth
factor induces Fos-like immunoreactivity within
identified cholinertgic neurons in the adult rat
basal forebrain, Brain Research 753: 141-151.
Gibbs, R.B., Hashash, A., and Johnson, D.A. (1997)
Effects of estrogen on potassium-evoked acetylcholine release in the
hippocampus and overlying cortex of adult rats, Brain Research 749: 143-146.
Okano, H.J., Pfaff, D.W., and Gibbs, R.B., (1996) Expression of EGFR-,
p75NGFR-, and PSTAIR (cdc2)-like Immunoreactivity by Proliferating Cells in the
Adult Rat Hippocampal Formation and Forebrain, Dev. Neurosci.
Gibbs, R.B. (1996) Expression of estrogen receptor-like immunoreactivity by
different subgroups of basal forebrain cholinergic neurons in gonadectomized
male and female rats, Brain Research 720: 61-68.
Gibbs, R.B. (1996) Fluctuations in Relative Levels of Choline Acetyltransferase
mRNA in Different Regions of the Rat Basal Forebrain Across the Estrous Cycle:
Effects of Estrogen and Progesterone, J. Neurosci.
Pfaus, J.G., A. Jakob, S.P.
Kleopoulos, R.B. Gibbs, and D.W. Pfaff, (1994) Sexual
stimulation induces Fos immunoreactivity within GnRH
neurons of the female rat preoptic area: interaction with steroid hormones, Neuroendocrinol. 60: 283-290.
Gibbs, R.B., D-H. Wu, L. Hersh, and D.W. Pfaff,
(1994) Effects of estrogen on relative levels of ChAT, TrkA and NGF mRNAs in
the rat forebrain and hippocampal formation, Exp. Neurol., 129: 70-80.
Gibbs, R.B. and D.W. Pfaff (1993) In situ hybridization detection of trkA mRNA
in brain: Distribution, co-localization with p75NGFR and up-regulation by nerve
growth factor. J. Comp. Neurol. 341: 324-339.
Koibuchi, N., R.B. Gibbs, K.E. Jones, S. Yamaoka,
W.W. Chin, D.W. Pfaff, and M. Suzuki (1993) Increase in c-erbAa2 mRNA in the parvocellular region of the paraventricular nucleus of the
hypothalamus following thyroidectomy detected by quantitative in situ hybridization
histochemistry in the adult male rat. Neurosci. Lett. 164: 159-162.
Pfaus, J.G., S.P. Kleopoulos,
C.V. Mobbs, R.B. Gibbs, and D.W. Pfaff, (1993) Fos and Jun expression in the female rat forebrain
following hormone treatment and sexual stimulation. Brain Research 624:
Okano, H.J., D.W. Pfaff, and R.B. Gibbs (1993) RB and cdc2 expression in the
adult rat brain: Correlations with 3H-thymidine incorporation. J. Neurosci. 13(7): 2930-2938.
Gibbs, R.B., M.M. McCarthy, D.W. Pfaff (1993) Nerve growth factor affects
defense-related behaviors, but not lordosis, in
ovariectomized, estrogen-treated rats. Brain Research 610: 256-266.
Okano, H.J., D.W. Pfaff, and R.B. Gibbs (1992) Role of local environmental
factors in determining tissue-specific effects of estrogen: Examination of
uterine tissues transplanted to brain. Molec. &
Cell. Endocrinol. 87: 179-192.
Gibbs, R.B. and D.W. Pfaff (1992) Effects of estrogen and fimbria/fornix
transection on p75NGFR and ChAT expression in the medial septum and diagonal
band of Broca. Experimental Neurology 16: 23-39.
Chastrette, N., D.W. Pfaff, and R.B. Gibbs (1991)
Effects of daytime and nighttime stress on Fos-like
immunoreactivity in the paraventricular nucleus of the hypothalamus and other
brain regions. Brain Research 563: 339-344.
Koibuchi, N., R.B. Gibbs, M. Suzuki, and D.W. Pfaff
(1991) Thyroidectomy induces Fos expression by
TRH-containing neurons located in the adult rat hypothalamus. Endocrinology
Gibbs, R.B., M.V. Chao, and D.W. Pfaff (1991) Effects of fimbria/fornix and
angular bundle transection on expression of the p75NGFR mRNA by cells in the
medial septum and diagonal band of Broca: Correlations with cell survival,
synaptic reorganization and sprouting. Molec. Brain
Res. 11: 207-219.
Gibbs, R.B. A. Lombardino, and D.W. Pfaff, (1990) Sex
steroids and Fos expression in the CNS of prepubertal and newborn rats. Molec.
and Cell. Neurosci. 1: 250-261.
Gibbs, R.B., C.V. Mobbs, and D.W. Pfaff, (1990) Sex
steroids and Fos expression in the rat brain and
uterus. Molec. and Cell. Neurosci. 1: 29-40.
Russell, M.J., V.K. Vijayan, R.B. Gibbs, J.W. Geddes,
C.H. Jacobson, and C.W. Cotman, (1990) Long-term
survival of neural transplants to senescence in rats. Exp. Neurol. 108:
Gibbs, R.B., J.T. McCabe, C.R. Buck, M.V. Chao, and D.W. Pfaff, (1989)
Expression of NGF receptor in the rat forebrain detected with in situ
hybridization and immunohistochemistry. Molec. Brain
Res. 6: 275-287.
Joyce, J.N., R.B. Gibbs, C.W. Cotman, and J.F.
Marshall, (1989) Regulation of muscarinic receptors in hippocampus following
cholinergic denervation and reinnervation by septal
and striatal transplants. J. Neurosci. 9: 2776-2791.
Joyce, J.N., R.B. Gibbs, C.W. Cotman, and J.F.
Marshall, (1989) Regulation of acetylcholine muscarinic receptors by embryonic
septal grafts showing cholinergic innervation of host hippocampus. Prog.in
Brain Res. 78: 109-115.
Anderson, K.J., R.B. Gibbs, and C.W. Cotman, (1988)
Transmitter phenotype is a major determinant in the specificity of synapses
formed by cholinergic neurons transplanted to the hippocampus. Neuroscience 25: 19-25.
Gibbs, R.B., J. Yu, and C.W. Cotman, (1987) Entorhinal transplants and spatial memory abilities in
rats. Behav. Brain Res. 26: 29-35.
Gibbs, R.B., D.L. Needels, J. Yu, and C.W. Cotman, (1987) Effects of entorhinal
lesions on trophic activities present in rat entorhinal
cortex and hippocampus as studied using primary cultures of entorhinal
and septal tissues. J. Neurosci. Res.
Gibbs, R.B. and C.W. Cotman, (1987) Factors affecting
survival and outgrowth from transplants of entorhinal
cortex. Neuroscience 21(3): 699-706.
Gibbs, R.B., K.J. Anderson, and C.W. Cotman, (1986)
Factors affecting innervation in the CNS: Comparison of three cholinergic cell
types transplanted to the hippocampus of adult rats. Brain Research 383:
Gibbs, R.B., S.K.R. Pixley, and C.W. Cotman, (1986) Transplantation of septal neurons maintained
in long-term culture. Brain Research 382: 409-415.
Anderson, K.J., R.B. Gibbs, P.M. Salvaterra, and C.W.
Cotman, (1986) Ultrastructural
characterization of identified cholinergic neurons transplanted to the
hippocampal formation of the rat. J. Comp. Neurol. 249:
Thompson, R., R.B. Gibbs, G.A. Ristic, C.W. Cotman, and J. Yu, (1986) Lack of correlation between
cortical levels of choline acetyltransferase and learning scores in rats with globuspallidus lesions. Brain
Research 367: 402-404.
Thompson, R., R.B. Gibbs, G.A. Ristic, C.W. Cotman, and J. Yu, (1986) Learning deficits in rats with
early neurotoxic lesions to the globuspallidus, substantia nigra, median raphe, or pontine reticular formation. Physiol. Behav.
Gibbs, R.B., E.W. Harris, and C.W. Cotman, (1985)
Replacement of damaged cortical projections by homotypic
transplants of entorhinal cortex. J. Comp. Neurol. 237: 47-64.
Cotman, C.W., M. Nieto-Sampedro,
and R.B. Gibbs (1984) Enhancing the self-repairing
potential of the CNS after injury. Central Nervous System Trauma 1(1): 3-14.
Gibbs, R.B. (2009) Animal Studies that Support Estrogen Effects on Cognitive Performance and the Cholinergic Basis of the Critical Period Hypothesis, In: Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies, E. Hogervorst, V. Henderson, R.B. Gibbs, and R. Brinton, Eds., Cambridge University Press, Cambridge, UK., 178-214.
Gibbs, R.B., (2006) Preclinical data relating to estrogenís effects on
cognitive performance, In: Estrogenís Effects on Brain Function: Whatís Next,
N. Rasgon, Ed. Johns Hopkins Press, Baltimore, MD,
Gibbs, R.B., (2002) Potential
mechanisms for the effects of estrogen on cognitive processes: role of basal forebrain
cholinergic projections, In: Neuroplasticity, Development, and Steroid Action, Handa, Hayashi, Terasawa, Kawata, Eds., CRC Press, Boca
Raton, FL, 117-129.
Gibbs, R.B. (2000) Oestrogen and the cholinergic
hypothesis: implications for estrogen replacement therapy in postmenopausal
women, In: Neuronal and Cognitive Effects of Oestrogens (Novartis Found. Symp.
230), J. Goode, Ed., Wiley, Chichester,
Gibbs, R.B. (2000) Effects of estrogen on basal forebrain cholinergic neurons
and cognition: implications for brain aging and dementia in women, In: Hormones
and Aging and Mental Disorders, ed. M. Morrison, Cambridge University Press,
Gibbs, R.B. (1994) Estrogen and nerve growth factor-related systems in brain:
effects on basal forebrain cholinergic neurons and implications for learning
and memory processes and aging, In: Hormonal Restructuring of the Adult Brain:
Basic and Clinical Perspectives, ed. V. H. Luine,
NYAS, NY, NY.
Nieto-Sampedro, M., P. Kesslak,
R.B. Gibbs, and C.W. Cotman, (1987) Effects of
conditioning lesions on transplant survival and connectivity. In: Cell and
Tissue Transplantation into the Adult Brain. Annal.
N.Y. Acad. Sci. 495: 108-119.
Cotman, C.W., R.B., Gibbs, and M. Nieto-Sampedro, (1987) Synapse turnover in the mammalian CNS. In:
The Dahlem Workshop Report: Neural and Molecular
mechanisms of Learning, Springer-Verlag, Berlin,
Cotman, C.W. and R.B. Gibbs, (1984) Methods for
transplanting CNS tissues to the CNS of adult and developing mammals. In: Plasticity
in Neurobiology: Cell to Behavior, Society for Neurosciences Short Course I