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University of Pittsburgh, Department of Family Medicine

Seymour Grufferman, M.D., Dr. P.H.
Professor

Publications:

(Asterisks denote student co-authors)

  • Kimm SYS, Grufferman S. Teaching rural health at Haile Selassie I University, Gondar Public Health College. Harvard Public Health Alumni Bulletin 1974;31:4-6.
  • Grufferman S, Duong T, Cole P. Occupation and Hodgkin's disease. J Natl Cancer Inst 1976;57:1193-5.
  • Grufferman S, Cole P, Smith PG, Lukes RJ. Hodgkin's disease in siblings. N Engl J Med 1977;296:248-50.
  • Grufferman S. Clustering and aggregation of exposures in Hodgkin's disease. Cancer 1977;39:1829-33.
  • Grufferman S, Alzheimer's disease and senile dementia: one disease or two? In: Katzman R, Terry RD, Bick KL, eds. Alzheimer's Disease: senile dementia and related disorders, Aging, Vol. 7. New York: Raven Press, 1978: 35-41.
  • Grufferman S, Kimm SYS. An epidemiologic approach to planning: a case study from Ethiopia. In: Maddox GL, ed. Assessment and Evaluation Strategies in Aging: People, Populations, and Programs. Durham, NC: Duke University Center for the Study of Aging and Human Development 1978:77-94.
  • Hainline SW*, Myers LE, McLelland R, Newell J, Grufferman S, Shingleton WW. Mammographic patterns and risk of breast cancer. Am J Roentgenol 1978; 130:1157-8.
  • Grufferman S. Is Hodgkin's disease transmissible: An epidemiologic appraisal. [Doctoral Dissertation]. Boston, MA: Harvard University, 1979.
  • Grufferman S, Cole P, Levitan TR. Evidence against transmission of Hodgkin's disease in high schools. N Engl J Med 1979;300:1006-11.
  • Hennekens C, Lown B, Rosner B, Grufferman S, Dalen J. Ventricular premature beats and coronary risk factors. Am J Epidemiol 1980;112:93-9.
  • Grufferman S, Gillman ME*, Pasternak LR*, Peterson CL*, Young WG Jr. Familial carotid body tumors: case report and epidemiologic review. Cancer 1980;46: 216-22.
  • Wang HH, Grufferman S. Aplastic anemia and occupational pesticide exposure: A case-control study. J Occup Med 1981;23:364-6.
  • Grufferman S. Epidemiologic approaches to the study of cancer. Proc Annu Meet Med Sect Am Counc Life Insur 1981;6:53-70.
  • Grufferman S. Hodgkin's disease. In: Schottenfeld D, Fraumeni JF Jr., eds. Cancer Epidemiology and Prevention, Chapter 42. Philadelphia: Saunders, 1982:739-53.
  • Grufferman S, Wang HH, DeLong ER, Kimm SYS, Delzell ES, Falletta JM. Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Natl Cancer Inst 1982;68:107-13.
  • Parry DM, Li FP, Strong LC, Carney JA, Schottenfeld D, Reimer RR, Grufferman S. Carotid body tumors in humans: Genetics and epidemiology. J Natl Cancer Inst 1982; 68:573-8.
  • Califf RM, Lee KL, Harrell FE Jr., Kimm SYS, Grufferman S, Rosati RA. Assessment of the use of the age- and sex-specific U.S. population as a control group for analysis of survival in coronary artery disease. Am J Cardiol 1982;50:1279-82.
  • Fisher A, Grufferman S. Stay healthy America! A new look at what you should know about cancer. Columbus, Georgia: American Family Corporation, 1982.
  • Greenberg RS*, Grufferman S, Cole P. An evaluation of space-time clustering in Hodgkin's disease. J Chronic Dis 1983;36:257-62.
  • Kimm SYS, Ornstein SM*, DeLong ER, Grufferman S. Secular trends in ischemic heart disease mortality: Regional variation. Circulation 1983;68:3-8.
  • Grufferman S, Delzell ES, Maile MC, Michalopoulos G. Parents' cigarette smoking and childhood cancer. Med Hypotheses 1983;12:17-20.
  • Delzell E, Grufferman S. Cancer and other causes of death among female textile workers, 1976-78. J Natl Cancer Inst 1983;71:735-40.
  • DeLong ER, Maile MC, Grufferman S. Climate, socioeconomic status and Hodgkin's disease mortality in the United States. J Chronic Dis 1984;37:209-13.
  • Grufferman S, Delzell ES, DeLong ER. An approach to conducting epidemiologic research within cooperative clinical trials groups. J Clin Oncology 1984;2:670-5.
  • Grufferman S, Kimm SYS, Maile MC. Teaching epidemiology in medical schools: A workable model. Am J Epidemiol 1984;120:203-9.
  • Grufferman S, Delzell ES. Epidemiology of Hodgkin's disease. Epidemiol Rev 1984;6:76-106.
  • Grufferman S. Multiple primary malignancy as a model for the study of cancer occurrence in rheumatoid arthritis. Am J Med 1985;78 (Suppl IA)65-8.
  • Delzell E, Grufferman S. Mortality among white and non-white farmers in North Carolina, 1976-1978. Am J Epidemiol 1985:121:391-402.
  • Johnston JM*, Grufferman S, Bourguet CC, Delzell ES, DeLong ER, Cohen HJ. Socioeconomic status and risk of multiple myeloma. J Epidemiol Community Health 1985;39:175-8.
  • McLendon RE, Robinson JS Jr., Chambers DB, Grufferman S, Burger PC. The glioblastoma multiforme in Georgia, 1977-1981. Cancer 1985;56:894-7.
  • Gutman LT, Grufferman S. Impact of medical school class ranking systems on applicants' ratings for residency positions. J Med Educ 1985;60:684-91.
  • Bourguet CC, Grufferman S, Delzell ES, DeLong ER, Cohen HJ. Multiple myeloma and family history of cancer: A case-control study. Cancer 1985;56:2133-9.
  • Grufferman S, Raab-Traub N, Marvin K, Borowitz MJ, Pagano JS. Burkitt's and other non-Hodgkin's lymphomas in adults exposed to a visitor from Africa. N Engl J Med 1985;313:1525-9.
  • Austin H, Delzell E, Grufferman S, Levine R, Morrison AS, Stolley PD, Cole P. A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking and alcohol consumption. Cancer Res 1986;46:962-6,
  • Fein AB, Rauch RF, Bowie JD, Pryor DB, Grufferman S. Value of sonographic screening for gallstones in patients with chest pain and normal coronary arteries. AJR 1986; 146:337-9.
  • Weston B*, Grufferman S, Kostyu D, Burton CS, Grant J. Familial aggregation of melanoma, basal cell carcinoma, and gastric adenocarcinoma. Cancer 1986;57:2230-4.
  • Grufferman S, Editorial. Cancer epidemiology at the Duke University Comprehensive Cancer Center: A cooperative venture involving practicing physicians and their patients. NC Med J 1986;47:461.
  • Yolles BJ, Connors JC, Grufferman S. Obtaining access to data from government sponsored medical research. N Engl J Med 1986;315:1669-72.
  • Cohen HJ, Bernstein RJ*, Grufferman S. The role of immune stimulation in the etiology of multiple myeloma: A case-control study. Am J Hematol 1987;24: 119-26.
  • Robertson SJ*, Lowman JT, Grufferman S, Kostyu D, van der Horst CM, Matthews TJ, Borowitz MJ, Bigner SH. Familial Hodgkin's disease: A clinical and laboratory investigation. Cancer 1987;59:1314-9.
  • Grufferman S, Barton JW*, Eby NL. Increased sex concordance of sibling pairs with Behcet's disease, Hodgkin's disease, multiple sclerosis and sarcoidosis. Am J Epidemiol 1987; 126:365-9.
  • Grufferman S. Discussion of epidemiologic studies assessing the role of the Epstein-Barr virus in Hodgkin's disease. Yale J Biol Med 1987;60:329-32.
  • Austin H, Delzell E, Grufferman S, Levine R, Morrison AS, Stolley PD, Cole P. A case-control study of hepatocellular carcinoma, occupation, and chemical exposures. J Occup Med 1987;29:665-9.
  • Weston B*, Grufferman S, MacMillan JP, Cohen HJ. Effects of socioeconomic and clinical factors on survival in multiple myeloma. J Clin Oncol 1987;5:1977-84.
  • Robertson SJ*, Grufferman S, Cohen HJ. Hospital versus random digit dialing controls in the elderly: Observations from two case-control studies. J Am Geriatr Soc 1988;36:119-23.
  • Saxinger WC, Polesky H, Eby N, Grufferman S, Murphy R, Tegtmeir G, Parekh V, Memon S, Hung C. Antibody reactivity with HBLV (HHV-6) in U.S. populations. J Virol Methods 1988;21:199-208.
  • Eby NL, Grufferman S, Gephart CM*, Schold SC Jr., Vogel FS. Increasing incidence of primary brain lymphoma in the U.S. Cancer 1988;62:2461-5.
  • Eby N, Grufferman S, Huang M*, Whiteside T, Sumaya C, Saxinger WC, Herberman R. Natural killer cell activity in the chronic fatigue-immune dysfunction syndrome. In: Ades EW and Lopez C, eds. Natural killer cells and host defense. Basel: Karger, 1989:141-5.
  • Grufferman S, Cohen HJ, Delzell S, Morrison MC*, Schold SC Jr., Moore JO. Familial aggregation of multiple myeloma and central nervous system disease. J Am Geriatr Soc 1989;37:303-9.
  • Walker A*, Schoenfeld ER, Lowman JT, Mettlin CJ, MacMillan J, Grufferman S. Survival of the older compared to younger patient with Hodgkin's disease: the influence of histology, staging and treatment. Cancer 1990;65:1635-40.
  • Olshan AF, Breslow NE, Daling JR, Falletta JM, Grufferman S, Robison LL, Waskerwitz M, Hammond WD. Wilm's tumor and paternal occupation. Cancer Res 1990;50:3212-7.
  • Schmader K, Studenski S, MacMillan JP, Grufferman S, Cohen, HJ. Are stressful life events risk factors for Herpes zoster? J Am Geriatr Soc 1990;38:1188-94.
  • Schluederberg A, Straus SE, Grufferman S, Guest Editors. Considerations in the design of studies of chronic fatigue syndrome. Rev Infect Dis 1991;13(Suppl 1).
  • Grufferman S. Issues and problems in the conduct of epidemiologic research on the chronic fatigue syndrome. Rev Infect Dis 1991;13(Suppl 1):S60-67.
  • Obrams GI, Grufferman S. Epidemiology of HIV-associated non-Hodgkin's lymphomas. In: Beral V, Jaffe H, Weiss R, eds. Cancer, HIV and AIDS. Cancer Surveys Series. Vol. 10. Cold Spring Harbor: Cold Spring Harbor Lab. Press, 1991:91-102.
  • Ruymann FB, Grufferman S. Chapter 1, Introduction and epidemiology of soft tissue sarcomas. In: Maurer HM, Ruymann FB, Pochedly CE., eds. Rhabdomyosarcoma and related tumors in children and adolescents. Boca Raton: CRC Press, 1991:3-18.
  • Grufferman S. Chapter 17, Epidemiologic and immunologic findings in clusters of chronic fatigue syndrome. In: Hyde BM, Goldstein J, Levine P, eds. The Nightingale Research Foundation Review of the Clinical and Scientific Basis of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome. Ottawa: Nightingale Research Foundation, 1992:189-95.
  • Ambinder RF, Browning PJ, Lorenzana I, Leventhal BG, Cosenza H, Mann RB, MacMahon EME, Medina R, Cardona V, Grufferman S, Olshan A, Levin A, Peterson EA, Blattner W, Levine PH. Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 1993;81:462-7.
  • Grufferman S, Schwartz AG, Ruymann FB, Maurer HM. Parents' use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children. Cancer Causes Control 1993,4:217-24.
  • Olshan AF, Breslow NE, Falletta JM, Grufferman S, Pendergrass T, Robison LLR, Waskerwitz M, Woods WG, Vietti TJ, Hammond GD. Risk factors for Wilms' tumor: Report from the National Wilms' Tumor Study. Cancer 1993;72:938-44.
  • Grufferman S, Steinbuch M. Utilisation parentale de la marijuana - et de la cocaine et risques de cancer chez leurs enfants. In: Mairie De Paris. III tme Colloque Scientifique International Sur Les Drogues Illicites. Paris: Mairie De Paris, 1994:227-31.
  • Macfarlane GJ, Evstifeeva TV, Boyle P, Grufferman S. International patterns in the occurrence of Hodgkin's disease in children and young adult males. Int J Cancer 1995;61:165-9.
  • Grufferman S. (Editorial) Is Hodgkin's disease infectious? Eur J Cancer 1995;31:1388-9.
  • Yang P, Grufferman S, Khoury MJ, Schwartz AG, Kowalski J, Ruymann FB, Maurer HM. Association of childhood rhabdomyosarcoma with neurofibromatosis type I and birth defects. Genet Epidemiol 1995;12:467-74.
  • Grufferman S. Chapter 38, Epidemiology and hereditary aspects of malignant lymphoma and Hodgkin's disease. In, Wiernik P, Canellos GP, Dutcher JP, Kyle RA, eds. Neoplastic Diseases of the Blood, 3rd Ed. Churchill Livingstone, NY, 1996;Section IV, Chapter 38:737-51.
  • Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Grufferman S, Member). Veterans and Agent Orange: Update 1996, Institute of Medicine, National Academy Press, Washington, DC, 1996.
  • Levine PH, Dale JK, Benson-Grigg E, Fritz S, Grufferman S, Straus SE. Clinical and immunologic studies of a cluster of women with chronic fatigue and chronic fatigue syndrome in a residential setting. CID 1996;23:408-9.
  • Zimmerman R, Bradley BJ, Janosky JE, Mieczkowski TA, DeSensi E, Grufferman S. Barriers to measles and pertussis immunization: the knowledge and attitudes of Pennsylvania primary care physicians. Am J Prev Med 1997;13:89-97.
  • Zimmerman RK, Medsger AR, Ricci EM, Raymund M, Mieczkowski TA, Grufferman S. Impact of free vaccine and insurance status on physician referral of children to public vaccine clinics. JAMA 1997;278:996-1000.
  • Grufferman S. Limitations of studies of childhood cancer in assessing dietary risk factors. In: Nitrite as a Food Additive: State of the Science. Georgetown University Center for Food and Nutrition Policy, 1998;88-95.
  • rufferman S. Methodologic approaches to studying environmental factors in childhood cancer. Environ Health Perspect 1998,106:881-6.
  • Grufferman S, Alexander FE. Preventable environmental causes of childhood cancer: Promise undelivered. J Epidemiol Biostat 1998;3:225-7.
  • Grufferman S. (Editorial) Complexity and the Hawthorne effect in community trials. Epidemiol 1999;10:209-10.
  • Mueller NE, Grufferman S. Hodgkin's disease: Chapter 5: Epidemiology. In: Mauch P, Armitage J, Diehl V, Hoppe R, Weiss L, eds. Hodgkin's Disease. Lippincott Williams & Wilkins, Philadelphia, PA. 1999:61-77.
  • Olshan AF, Smith J, Cook MN, Grufferman S, Pollock BH, Stram DO, Seeger RC, Look AT, Cohn SL, Castleberry RC, Bondy M. Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children's Cancer Group and Pediatric Oncology Group. Am J Epidemiol, 1999; 150: 930-8.

    Letters to the Editor:

  • Grufferman S, Cole P, Smith PG, Lukes RJ. Reasons for familial aggregation in Hodgkin's disease. N Engl J Med 1977;296:940-1.
  • Grufferman S, Cole P. Interaction between sex and HLA type in Hodgkin's disease. Arch Neurol 1984;41:816.
  • Grufferman S, Kimm SYS. Clinical epidemiology defined. N Engl J Med 1984;311:541-2.
  • Capps JL*, Delzell E, Bourguet CC, Grufferman S. Causes of neonatal mortality. JAMA 1984;252:1853-4.
  • Austin H, Delzell E, Cole P, Grufferman S, Levine R, Morrison A, Stolley PD. Correspondence re: Harland Austin et al. A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Cancer Res 1986;46:962-966. Cancer Res 1987;47:654-5.
  • Yolles BJ, Connors JC, Grufferman S. Obtaining access to data from government-sponsored medical research. N Engl J Med 1987:317:57-8.
  • Yolles BJ, Grufferman S. Malpractice and the quality of care. N Engl J Med 1987;317:1353.
  • Grufferman S, Markle WH, Middleton DB. Worms and the historical overload syndrome. J Fam Pract 1995;41:5.

    Published Abstracts:

  • Lown B, Hennekens CH, Rosner B, Grufferman S. Ventricular premature beats and coronary risk factors. Am J Epidemiol 1978;108:228.
  • Grufferman S, Kimm SYS, Wang HH. Teaching of epidemiology in medical schools: The Duke experience. Am J Epidemiol 1979;110:364-5.
  • Shingleton WB*, Keil J, Grufferman S. A case-control study of cancer of the pancreas Am J Epidemiol 1979;110:357-8.
  • Grufferman S, Wang HH, DeLong ER, Kimm SYS. Environmental factors in the etiology of childhood rhabdomyosarcoma. Am J Epidemiol 1980;112:423.
  • Ornstein SM*, Kimm SYS, DeLong ER, Grufferman S. Analyses of secular trends in ischemic heart disease mortality in North Carolina. Am J Epidemiol 1981;114:448.
  • Ornstein SM*, Kimm SYS, DeLong ER, Grufferman S. Analyses of regional variations in ischemic heart disease mortality trends. Circulation 1981;64 (Supp IV):250.
  • Califf R, Ornstein SM*, Kimm SYS, Grufferman S, Lee K, Rosati R. Use of the age and sex specific population for analysis of survival in coronary disease. Circulation 1981;64 (Supp IV):91.
  • Grufferman S, Cohen HJ, Morrison MC*, Delzell ES, Schold SC Jr., DeLong ER. Familial aggregation of multiple myeloma and central nervous system disease. Clin Res 1982;30:418A.
  • Grufferman S, Delzell ES, DeLong ER, Maile MC. An approach to conducting epidemiologic research in cooperative clinical trials groups. Proc Am Assoc Cancer Res 1983;24:190.
  • Grufferman S, Hofbauer CJ, Marvin K, Raab-Traub N, Borowitz MJ, Cornwell SB*, Haynes BF, Pagano JS. Burkitt's and other non-Hodgkin's lymphomas in adults exposed to a visitor from Africa. Am J Epidemiol 1984;120:499.
  • Bourguet CC, Grufferman S, Delzell ES, DeLong ER, Cohen HJ. Aggregation of cancer in families of multiple myeloma cases. Am J Epidemiol 1984;120:483.
  • Fein AB, Rauch RF, Bowie JD, Rosenberg ER, Pryor DB, Grufferman S. Prevalence of sonographically proven cholelithiasis in patients with chest pain and normal coronary arteries referred for ultrasound of the gallbladder. Invest Radiol 1984;19:S5.
  • Cohen HJ, Bernstein RJ*, Grufferman S. An evaluation of immune stimulation in the etiology of multiple myeloma. Blood 1985;66 Suppl 1:186a.
  • Weston B*, Grufferman S, MacMillan JP, Cohen HJ. Effects of socioeconomic and clinical factors on survival in multiple myeloma. Proc Am Soc Clin Oncology 1986;5:214.
  • Weston B*, Grufferman S, MacMillan JP, Cohen HJ. Effects of socioeconomic factors on survival in multiple myeloma. Clin Res 1986;34-387A.
  • Eby N, Grufferman S, Leffingwell DP, Gephart CM*, Schold SC. Increasing incidence of primary brain lymphoma in the elderly. Am J Epidemiol 1987; 126:755.
  • Eby N, Grufferman S, Whiteside T, Herberman R. Natural killer cell activity as a marker of immune dysfunction in the chronic fatigue syndrome. Nat Immun Cell Growth Regul 1988;7:48-9.
  • Grufferman S, Eby NL, Huang M*, Whiteside T, Sumaya CV, Saxinger WC, Herfkens RJ, Penkower L, Muldoon SB*, Herberman RB. Epidemiologic investigation of an outbreak of chronic fatigue-immune dysfunction syndrome in a defined population Am J Epidemiol 1988;128:898.
  • Olshan A, Breslow N, Falletta J, Grufferman S, Pendergrass T, Robison L, Strong L, Waskerwitz W, Woods W, Hammond D. A case-control study of risk factors for Wilms' tumor: Report from the National Wilms' Tumor Study. Med Pediatr Oncol 1988; 16:413.
  • Kimm SYS, Foley EC, Grufferman S. Primary prevention in primary care: Fact or fiction? Prevention 90 Program Book, 1990.
  • Grufferman S, Olshan AF, Gula MJ, Maurer HM. The role of active immunization in the etiology of childhood cancer: Protective or simply proscribed? Am J Epidemiol 1990; 132:758.
  • Jacobson L, Munoz A, Dudley J, Grufferman S, Obrams I, Armenian H, Phair J. Timing of potential Kaposi's sarcoma cofactor. Am J Epidemiol 1990;132:771.
  • Grufferman S, Gula MJ, Olshan AF, Falletta JM, Ruymann FB, Buckley J, Pendergrass TW, Maurer HM. Parents' use of recreational drugs and risk of rhabdomyosarcoma in their children. Am J Epidemiol 1991;134:767.
  • Grufferman S, Gula MJ, Olshan AF, Falletta JM, Buckley J, Pendergrass TW, Maurer HM. Absence of an association between parents' cigarette smoking and risk of rhabdomyosarcoma in their children. Paediatr Perinat Epidemiol 1991;5:A17.
  • Grufferman S, Gula MJ, Olshan AF, Falletta JM, Pendergrass TW, Buckley J, Maurer HM. In utero X-ray exposure and risk of childhood rhabdomyosarcoma. Paediatr Perinat Epidemiol 1991;5:A6.
  • Grufferman S, Gula MJ, Olshan AF, Falletta JM, Pendergrass TW, Buckley J, Maurer HM. Experience with random digit telephone dialing for control selection in a casecontrol study of children. Paediatr Perinat Epidemiol 1991:5:A17-8.
  • Yang P, Grufferman S, Schwartz AG, Gilchrist G, Leventhal B. A genetic analysis of Hodgkin's disease. Am J Hum Genet 1993;53(3):A391.
  • Grufferman S, Stone RA, Eby NL, Huang MS*, Muldoon SB*, Penkower L. Closeness of contacts between people in two clusters of chronic fatigue syndrome; evidence for an infectious etiology? Clin Infect Dis 1994;18(Suppl 1):S54-5.
  • Grufferman S, Levine PH, Eby NL, Muldoon SB*, Huang MS*, Whiteside TL, Penkower L, Herberman RB. Results of an investigation of three clusters of chronic fatigue syndrome. Clin Infect Dis 1994;18(Suppl 1):S55-6.
  • Yang P, Grufferman S, Schwartz AG, Kowalski J, Ruymann FB, Maurer HM. The association between childhood rhabdomyosarcoma and neurofibromatosis type I and congenital abnormalities. Paediatr Perinat Epidemiol 1994; 8(4):A2.
  • Grufferman S, Chauvenet A, Gilchrist G. Familial aggregation of childhood Hodgkin's disease and other cancers. A report from the Children's Cancer Group and the Pediatric Oncology Group. Proceedings of the Third International Symposium on Hodgkin's Lymphoma 1995:63.
  • Grufferman S, Baglietto L, Boyle P, Ruymann F, Maurer H. Fathers' military service, exposure to Agent Orange and risk of rhabdomyosarcoma in their children. Am J Epidemiol 1997;145:S4.
  • Grufferman S, Ambinder RF, Shugart YY, Brecher ML, Gilchrist GS. Increased cancer risk in families of children with Hodgkin's disease. Am J Epidemiol 1998;147(11)29.
  • Grufferman S, Davis MK, Ambinder RF, Shugart YY, Gilchrist GS, Brecher ML. A protective effect of breast-feeding on risk of Hodgkin's disease in children. Paediatr Perinat Epidemiol 1998;12:A13.