Biological Sciences 1540
Computational Biology
Fall Term 2011

Class Schedule:

Date Lecture topic Instructor Reading Assignment
29-Aug Intro/Molecular Biology Review Eric Polinko  
31-Aug Introduction to CompBio/Bioinformatics EP Ch1: 1-13, 17-19
2-Sep **LAB** The Internet, Networking, & Unix EP
5-Sep ***NO CLASS - LABOR DAY***
7-Sep Genomics I EP  
9-Sep **LAB** NCBI & UniProt
EP

 

12-Sep Genomics vs Proteomics
**Project Part I due**
EP

Ch 1: 20-26, 32-36

14-Sep Sequencing Genomes
Dan Russell  
16-Sep

Proteomics

EP

Ch 9: 380-385, 391-394, 402

19-Sep

Turning Junk (DNA) into Gold
**Homework** - BLAST

Mark Rebeiz  
21-Sep **LAB** GenePalatte MR  
23-Sep

Biological Sequence Databases

EP

Ch 4: 149-157, 177-183

26-Sep Sequence Database Searching - Scoring Matrices EP Ch 4: 162-167
28-Sep Gene Expression Analysis using MicroArrays Uma Chandran Ch 9: 394-402
30-Sep

Sequence Database Searching - Algorithms

EP  
3-Oct **LAB**ClustalX/Jalview
EP Ch 4: 162-167
5-Oct Sequence Database Searching - BLAST & Statistics EP Ch 4: 168-169
7-Oct

Phylogenetics
**(Project Part II due)**

Tony Bledsoe
10-Oct ***FALL BREAK - CLASS ON TUESDAY***
11-Oct Comparative Genomics of BacterioPhage Graham Hatfull  
12-Oct Comparative Genomics of Bacteria

Jon Boyle

 
14-Oct Viral Metagenomics Joshua Katz  
17-Oct Multiple Sequence Alignment & Psi-Blast EP Ch 4: 170-176
19-Oct **LAB** - Advanced Jalview & Exam Review
EP
21-Oct EXAM I EP
24-Oct Mass Spectrometry Mark Bier Ch 9: 386-391
26-Oct **LAB** - Protein ID via Virtual Mass Spec MB  
28-Oct

Intro to Protein Structure

Swarna Mohan

Ch2: 42-52
Ch4: 156-157

31-Oct Solving Protein Structure via X-ray Crystallography Andy VanDemark Ch3: 96-111
2-Nov **LAB** - VMD
(Project Part III due)
EP Ch1: 20-21
4-Nov Hidden Markov Models Sabah Kadri
7-Nov **LAB** - WinCoot Andy VanDemark  
9-Nov Molecular Dynamics I Joshua Adelman Ch3: 137-139
11-Nov Molecular Dynamics II JA
14-Nov Molecular Simulation Approaches Lillian Chong  
16-Nov **LAB** - NAMD JA
18-Nov **LAB** - NAMD JA  
21-Nov **LAB**- Visualize/Analyze MD
JA
23/25-Nov ***NO CLASS - THANKSGIVING***
28-Nov

QM/MM
(Project Part IV due 2morrow)

Troy Wymore
30-Nov Bioinf/CompBio career day
Adam Kraut
2-Dec Brain Imaging Greg Hood
5-Dec Visualization & Analysis of Volumetric
Biomedical Images
Art Wetzel
7-Dec EXAM II  
9-Dec **LAB** - 3D room at NBRSC Hood & Wetzel
16-Dec FINAL ==> Project Presentations (9-10:50am)




Last Updated: 1 December 2011
Question or Comments: epolinko@pitt.edu
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