This project:

	Drug production is made less expensive and more efficient by catalysts. The rhodium (Rh) center is a catalyst. The special nature of our ligand is to wrap around the metal and create a right or left handed environment that closely surrounds the metal catalyst.

Objective:    The development of new synthetic methods for creating chiral N-hetrocyclic carbene (NHC) ligands and demonstrating improved selectivity and reaction rate for these second generation NHC ligands. Significance:    Manufacture of complex micron-scale objects will require the self-assembly of sub-micron components. The assembly of these components can be controlled by their surface chemical features. Our research evaluates new ways to label microspheres and nanotubes with chemically distinct domains.

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	Scheme 1. Synthetic method developed by Xiaohong Pan, third year graduate student. The route is convergent and will allow small ‘libraries’ of chiral caducean ligands to be efficiently prepared.

Progress: We are now testing how the size, shape, and polarity of our ‘hands’ influence catalyzed reactions. Recently prepared ligands show high selectivity and good reaction rate.

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