I graduated from Joint CMU-Pitt Ph.D. Program in Computational Biology (CPCB) at the Department of Computational & Systems Biology in University of Pittsburgh. I worked with Drs. Tim Lezon and Lans Taylor.

Research Interests

  • Mathematical, statistical and mechanistic, modeling of signaling cascades
  • Systems biology of cancer cells
  • Quantitative Systems Pharmacology (QSP)


  1. Erdem, C, Nagle AM, Casa AJ, Litzenburger B, Wang Y, Taylor DL, Lee AV, Lezon TR. Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways. Molecular & Cellular Proteomics. 15 (9), 3045-3057. [Published ahead of print on June 30] 
  2. Erdem C, Bozkurt Y, Erman B, Gul A, Demir A. Mathematical Modeling of Behcet's Disease: A dynamical systems approach. Journal of Biological Systems. 23 (02), 231-57.


  1. "Insulin receptor substrate (IRS) dictates differential responses to insulin and insulin-like growth factor I (IGF1) stimulation". 18th International Conference on Systems Biology 2017, Blacksburg, VA, USA.
  2. "Specific interactions of the adaptor proteins dictate differential responses downstream of IGF1R and InsR". The Eleventh q-bio Conference 2017, New Brunswick, NJ, USA.
  3. "Unraveling novel differential responses to insulin and insulin-like growth factor I in breast cancer by computational modeling". ASCB Annual Meeting 2015, San Diego, CA, USA.
  4. "Unraveling novel differential responses to insulin and insulin-like growth factor I in breast cancer by computational modeling". University of Pittsburgh BGSA Symposium 2015, Pittsburgh, PA, USA.
  5. "Characterization of differences in IGF1 and insulin induced proteomic signaling cascades". The Ninth q-bio Conference 2015, Blacksburg, VA, USA.
  6. "Mathematical Modeling of Behcet's Disease". RECOMB 2012, Barcelona, Spain.

Contributed work

  1. Poster: "IGF1 and insulin repress MAPK signaling in Her2-Amplified Breast Cancer Cell Lines". Nagle AM et al. ENDO 2015, San Diego, CA, USA.
  2. Poster: "Mathematical Modeling of Behcet's Disease: A Dynamical Systems Approach". 16th International Conference on Behcet's Disease, Paris, France.


2012-present: Ph.D. in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA
PhD thesis: "Employing QSP to characterize differences in IGF1 and insulin signaling pathways in breast cancer"
Advisors: Dr. D. Lansing Taylor & Dr. Timothy R. Lezon

2010-2012: M.Sc. in Chemical and Biological Engineering, Koc University, Istanbul, Turkey
Masters thesis: "Mathematical Modeling of Behcet's Disease"
Dr. Burak Erman & Dr. Alper Demir

2006-2010: B.S. in Chemical Engineering, Middle East Technical University, Ankara, Turkey
Undergraduate thesis: "Kinetics modeling of the effect of medium pH on recombinant EPO production by Pichia pastoris"
r: Dr. Pınar Calık

Teaching Experience

  1. Fall 2013: Teaching Assistant for Computational Structural Biology, University of Pittsburgh, USA
  2. Spring 2012: Teaching Assistant for Undergraduate Thermodynamics, Koc University, Turkey
  3. Fall 2011: Teaching Assistant for Advanced Thermodynamics & Thermostatistics, Koc University, Turkey
  4. Spring 2011: Teaching Assistant for Undergraduate Thermodynamics, Koc University, Turkey

Contact: cemalerdem@pitt.edu

Last updated: May 18, 2018