Department of Orthopedic Surgery LIVE CELL IMAGING LAB
Stem Cell Research Center McGowan Institute for Regenerative Medicine
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Yuko Sakaguchi Askew, M.D./ Ph.D.

Research Associate

5106 Rangos Research Center
3460 Fifth Avenue
Pittsburgh, PA, USA 15213
ykskgcak1967@gmail.com


Education

M.D. Yamaguchi University School of Medicine, Japan, 1993
Ph.D. Yamaguchi University, Japan, Molecular Biology, 1999



Current Research

Live Cell Imaging and stem cell biology
Development of molecular tools for live cell imaging
Chracterization of human stem cells

Publications (3 of 31)

1. David J. Askew, Sule Cataltepe, Vasantha Kumar, Christopher Edwards, Serena M. Pace, Rica N. Howarth, Stephen C. Pak, Yuko Askew, Dieter Bromme, Cliff J. Luke, James C. Whisstock, and Gary A. Silverman. "Serpinb11 is a new non-inhibitory intracellular serpin: Common single nucleotide polymorphisms in the scaffold impair conformational change." J. Biol. Chem 2007 Aug 24, 282(34):24948-60.

2. Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Brömme D, Silverman GA. "An intra- cellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury." CELL 2007 Sep21, 130(6):1108-19.

3. Askew YS, Pak SC, Luke CJ, Askew DJ, Cataltepe S, Mills DR, Kato H, Lehoczky J, Dewar K, Birren B, Silverman GA. "SERPINB12 is a novel member of human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases." J Biol Chem 2001, 276:49320-30.
Awards

2001 Shinjinkai-Award, Dept of OB/GYN Yamaguchi University School of Medicine, Japan