Akira Sekikawa

Akira Sekikawa M.D., M.P.H., Ph.D., Ph.D.

Assistant Professor of Epidemiology
Graduate School of Public Health
University of Pittsburgh

Adjunct Associate Professor
Department of Health Science

130 North Bellefield Avenue, Suite 546
Pittsburgh PA, 15213, USA
Voice: 412-624-3225
E-mail: akira@pitt.edu

Education	Ph.D., University of Pittsburgh 1999
	M.P.H., University of Pittsburgh, 1996
	Ph.D., Yamagata University, 1990
	M.D., Tohoku University, 1983

Research Interests	Cardiovascular Epidemiology
	Diabetes Epidemiology
	Epidemiology and Prevention
	Epidemiology in Japanese populations

Research Supports	Principal Investigator
	Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan (2008-2013) R01 HL 068200 Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan (2003-2007) R01 HL068200
	A population-based study of intima media thickness of the carotid artery in Koreans as compared with Americans and the Japanese (2005-2007) University of Pittsburgh
	Epidemiology of subclinical atherosclerosis evaluated by EBCT and risk factors in men in the post World War II birth cohorts in the US and Japan (2001-2003) American Heart Association Beginning Grant in Aid Award
	Co Principal Investigator
	Epidemiology and Internet (2000-2004) NIH/NLM

Honor	Fellow, Council of Epidemiology and Prevention, American Heart Association, 2001
	University of Pittsburgh Cancer Institute, Scientific Award, 2001
	Delta Omega Society, 1999
	Japanese Society of Internal Medicine Award, 1991

Recent refereed Publications (2006-2011)

1. Sekikawa A, Kadowaki T, El-Saed E, Okamura T, Sutton-Tyrrell K, Nakamura Y, Evans EW, Mitsunami K, Edmundowicz D, Nihio Y, Nkata K, Kadota A, Otake T, Miura K, Choo, J, Abbott RD, Kuller LH, Ueshima H. Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. Stroke (In Press)

2. Hassen LJ, Ueshima H, Curb JD, Choo J, Lee S, Masaki K, Kadowaki T, Shin C, Evans EW, Seto TB, Fujiyoshi A, Wilcox BJ, Sutton-Tyrrell K, Kadota A, El-Saed A, Miura K, Kuller LH, Sekikawa A (corresponding author). Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans. European Journal of Clinical Nutrition (In Press)

3. Lee S, Curb JD, Kadowaki T, Evans RW, Miura K, Takamiya T, Shin C, El-Saed A, Choo J, Fujiyoshi A, Otake T, Kadowaki S, Seto T, Masaki K, Edmuncowicz D, Ueshima H, Kuller LH, Sekikawa A (corresponding author) Significant inverse association of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. British Journal of Nutrition (In Press)

4. Fujiyoshi A, Kadowaki T, Kadowaki S, Sekikawa A, Ohkubo T, Miura K, Edmundowicz D, Budoff M, Murata K, Liu K, Ueshima H. Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies. International Journal of Cardiology 2011 (In Press)

5. Azuma RW, Kadowaki T, El-Saed A, Ueshima H, Sutton-Tyrrell K, Nakamura U, Edmundowicz D, Ueno Y, Evans RW, Kadota A, Kuller LH, Murata K, Takamiya T, Kadowaki S, Curb JD, Sekikawa A (corresponding author) Lower levels of von Willebrand factor in US White than Japanese men in Japan aged 40-49. Acta Cardiologica 2010; 65: 449-56

6. Sekikawa A, Kadowaki　T, Curb JD, Evans RW, Maegawa H, Abbott RD, Kim Sutton-Tyrrell K, Okamura T, Shin C, Edmundowicz D, Kadota A, Choo J, El-Saed A, Ueshima H, Kuller LHfor the ERA JUMP Study group, Circulating levels of eight cytokines and marine n-3 fatty acids and indices of obesity and in Japanese, white and Japanese American middle-aged men. Cytokine Research 30: 541-8; 2010

7. Nakata K, Choo J, Hopson MJS, Ueshima H, Curb JD, Shin C, Evans RW, Kadowaki T, Otake T, Kadota A, Kadowaki S, Miura K, El-Saed A, Edmundowicz D, Sutton-Tyrrell K, Kuller LH, Sekikawa A. Stronger Associations of Sagittal Abdominal Diameter with Atherogenic Lipoprotein Subfractions than Waist Circumference in Middle-Aged U.S. Whites and Japanese Men. Metabolism 59: 1742-51: 2010

8. Choo　J, Ueshima　H, Curb　JD,　Shin C, Evans RW, El-Saed A, Kadowaki T, Okamura T, Nakata K, Otake T, Miura K, Abbott RD, Sutton-Tyrrell K, Edmundowicz D, Kuller LH, Sekikawa A. Serum n-6 Fatty Acids and Lipoprotein Subclasses in Middle-Aged Men: A population-Based Cross-Sectional ERA-JUMP Study　Am J Clin Nutr 91; 1195-1203; 2010

9. Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, Evans RW, Edmundowicz E, Curb JD, Ueshima H for ERA JUMP Research Group. Visceral and Subcutaneous Adiposity and Serum Adiponectin in Middle-aged Japanese Men: The ERA JUMP Study. International Journal of Obesity 17; 1269-73:2009

10. Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott RD, Curb JD, Edmundowicz D,Nakamura Y, Murata K, Kashiwagi A, Sutton-Tyrrell K, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K, Nisio Y, Miljkovic-Gacic I, Horie M, Miyamastu N, Murakami Y, Kuller LH, Ueshima H. Cholesteryl Ester Transfer Protein, Coronary Calcium and Intima-media Thickness of the Carotid Artery in Middle-Aged Japanese Men. Am J Cardiolo 104; 818-22: 2009

11. Motoyama KR, Curb JD, Kadowaki T, El-Saed A, Abbott RD, Okamura T, Evans RW, Nakamura Y, Sutton-Tyrrell K, Rodriguez BL, Kadota A, Edmundowicz D, Willcox BJ, Choo J, Katsumi N, Otake T, Kadowaki S, Kuller LH, Ueshima H, Sekikawa A (corresponding author). The association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in three populations of middle-aged men. Am J Clin Nutr 90; 49-55: 2009

12. Azuma K, Kadowaki T, Cetinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, Nihio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A (corresponding author). Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the US. Metabolism 58; 1200-7; 2009

13. Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, Watanabe M, Kadota A, Okuda N, Kadowaki T, Nakamura Y, Okamura T: Cardiovascular disease and risk factors in Asia: a selected review. Circulation 118:2702-2709, 2008

14. Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RL, Kuller LH. Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese Americans, and Whites. J Am Coll Cardiol 2008; 52: 417-24

15. Sekikawa A, Ueshima H, Sutton-Tyrrell K, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Ueno Y, Evans RW, Nakamura Y, Edmundowicz D, Kashiwagi A, Maegawa H, Kuller LH. Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40-49 between whites in the U.S. and the Japanese in Japan for the ERA JUMP Study. Metabolism 2008;57:177-82

16. Choo J, Ueshima H, Jang Y, Sutton-Tyrrell K, El-Saed A, Kadowaki T, Takamiya T, Okamura T, Ueno Y, Nakamura Y, Sekikawa A, J. Curb D, Kuller LH, Shin C. Difference in carotid intima-media thickness between Korean and Japanese men. Ann Epidemiology. 2008; 18:310-5

17. El-Saed A, Sekikawa A, Edmundowicz D, Evans RW, Sutton-Tyrrell K, Kadowaki T, Choo J, Takamiya T, Kuller LH. Coronary Calcification is More Predictive of Carotid Intimal Medial Thickness in Black Compared to White Middle Aged Men. Atherosclerosis 2008; 196; 913-8

18. Abbott RD, Ueshima H, Rodriguez BL, Kadowaki T, Masaki KH, Willcox BJ, Sekikawa A, Kuller LH, Edmundowicz D, Shin C, Kashiwagi A, Nakamura Y, El-Saed A, Okamura T, White R, J. Curb D. Coronary Artery Calcification in Japanese Men in Japan and Hawaii. Am J Epidemiol 2007; 166: 1280-7

19. El-Saed A, Sekikawa A, Zaky RW, Kadowaki T, Takamiya T, Okamura T, Edmundowicz D, Kita Y, Kuller LH, Ueshima H. Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men J Epidemiology 2007; 17:179-85

20. Nakamura, Y, Ueno Y, Tamaki S, Kadowaki T, Okamura T, Kita Y, Miyamatsu N, Sekikawa A, Takamiya T, El-Saed A, Sutton-Tyrell K, Ueshima H. Fish Consumption and Early Atherosclerosis in Middle-Aged Men. Metabolism 2007;56:1060-4

21. Sekikawa A, Ueshima H, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Kashiwagi A, Edmundowicz D, Murata K, Sutton-Tyrrell K, Maegawa H, Evans R, Kita Y, Kuller L. Less subclinical atherosclerosis in Japanese men in Japan than in white men in the United States in the post World-War-II birth cohort Am J Epidemiol 2007; 165: 617-24

22. Kadowaki T, Sekikawa A, Okamura T, Takamiya T, Kashiwagi A, Zaky WR, Maegawa H, El-Saed A, Nakamura Y, Evans RW, Edmundowicz D, Kita Y, Kuller L. Ueshima H. Higher levels of adiponectin in American than in Japanese men despite obesity. Metabolism 2006; 55:1561-3

23. Matsunaga-Irie S, Ueshima H, Zaky WR, Kadowaki T, Evans RW, Okamura T, Takamiya T, Kita Y, Kuller LH, Sekikawa A. Serum ghrelin levels are higher for men 40-49 years of age in the U.S. than Japan. Diabetes, Obesity and Metabolism (In Press)

24. Okamura T, Kadowaki T, Sekikawa A, Murata K, Miyamatsu N, Nakamura Y, El-Saed A, Kashiwagi A, Maegawa H, Nishio Y, Takamiya T, Kanda H, Mitsunami K, Kita Y, Edmundowicz D, Tamaki S, Tsujita Y, Kuller LH, Ueshima H, Alcohol consumption and coronary artery calcium in middle-aged Japanese men. Am J Cardiol 2006; 98:1414-4

25. Kadowaki T, Sekikawa A, Murata K, Maegawa H, Takamiya T, Okamura T, El-Saed, A, Miyamatsu N, Edmundowicz D, Kita Y, Sutton-Tyrrell K, Kuller LH, Ueshima H. Large visceral visceral fat in Japanese than Caucasian men. International Journal of Obesity 2006; 7:1163-5

26. Takamiya T, Kadowaki T, Zaky WR, Ueshima H, Evans RW, Okamura T, Kashiwagi A, Nakamura Y, Kita Y, Tracy RP, Kuller LH, Sekikawa A. The Determinants of Plasma Plasminogen Activator Inhibitor 1 Levels differ for American and Japanese Men Aged 40-50. Diab Res Clin Prac 2006; 72: 176-82