Our group has developed an easy to use method for chemical immobilization of organophosphate-hydrolyzing enzymes in poly(urethane) coatings that are widely used to coat a number of equipments. We are interested in tailoring interactions between the biocatalysts immobilized in coatings with their substrates. We have approached this problem in a variety of ways schematically shown below. Coatings made porous by porogens increased the enzyme activity by four fold. Hydrophobic modifications that facilitate accumulation at the air-water interface were used to modify the native enzyme DFPase and "pull" it to the surface during the curing process. Our next goal is to make inorganic catalyst and biocatalyst containing hybrid coatings, which can withstand UV radiations and retain the activity of both catalysts.