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Aaron Barchowsky - Publications

Refereed Articles - past 5 years

  1. Soucy, NS, MA Ihnat, L Hess, DK Chandrashekhar, LR Klei, C Clark, M Post, and A Barchowsky. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci, 76:271-279, 2003. PMID: 12970581 (voted best paper of 2004).

  2. Soucy, NS, LR Klei, DD Mayka, and A Barchowsky. Signaling Pathways for Arsenic-Stimulated Vascular Endothelial Growth Factor-A Expression in Primary Vascular Smooth Muscle Cells. Chem Res Toxicol. 17:555-563, 2004. Abstract

  3. Gao F, A Barchowsky, AA Nemec, and JP Fabisiak. Microbial stimulation by mycoplasma fermentans synergistically amplifies IL-6 release by human lung fibroblasts in response to residual oil fly ash (ROFA) and nickel. Toxicol Sci 81:476-479, 2004. Abstract

  4. Shenberger JS, JL Myers, SG Zimmer, RJ Powell, and A Barchowsky. Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation. Am J Physiol Lung Cell Mol Physiol. 288:L442-L449, 2005. PMID: 15542544

  5. Soucy, NV, DD Mayka, LR Klei, AA Nemec, JA Bauer, and A Barchowsky. Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice. Cardiovasc Toxicol 5 29-41, 2005. PMID: 15738583

  6. O'Hara, KO, AA Nemec, J Alam, LR Klei, BT Mossman, and A Barchowsky. Chromium(VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells. J. Cell. Physiol. 209:113–121, 2006. PMID: 16775837

  7. Straub, AC, DB Stolz , MA Ross, A Hernandez, V Soucy, LR Klei, and A Barchowsky. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 45:205-212, 2007. PMID: 17187425

  8. O'Hara, KO, RJ Vaghjiani, AA Nemec, LR Klei, and A Barchowsky. Chromium(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck. Biochem J. 402:261-269, 2007. PMID: 17078813

  9. Straub, AC, DB Stolz, H. Vin, MA Ross, NV Soucy, LR Klei, and A Barchowsky. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol. Appl. Pharmacol. 222:327-336, 2007 PMID: 17123562

  10. Shenberger JS, L Zhang, RJ Powell, and A Barchowsky.  Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes. Free Radic Biol Med. 43:844-852, 2007. PMID: 17664148

  11. Zhao, J, RW Harper, A Barchowsky, YP Di. Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 293:L480-l490, 2007. PMID: 17496060

  12. Shvedova, A.A., Fabisiak, J.P., Kisin, E.R., Murray, A., Roberts, J., Antonini, J., Kommineini, C., Reynolds, J., Barchwosky, A., Castranova, V., and Kagan, V.E. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am. J. Respir. Cell Molec. Biol., In Press.

  13. Klei, L R and Barchowsky, A. Positive Signaling Interactions between Arsenic and Ethanol for Angiogenic Gene Induction in Human Microvascular Endothelial Cells. Toxicol Sci. 2008 Apr;102(2):319-27. Epub 2008 Jan 8. PMID: 18182400

  14. Basu P, Ghosh RN, Grove LE, Klei L, Barchowsky A. Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic Acid (roxarsone). Environ Health Perspect. 2008 Apr;116(4):520-3. PMID: 18414637

  15. Dougherty D, Garte S, Barchowsky A, Zmuda J, Taioli E. NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure-A literature review.  Toxicol Lett. 2008 Sep 20.  PMID: 18848868

  16. Straub AC, Clark KA, Ross MA, Chandra AG, Li S, Gao X, Pagano PJ, Stolz DB, Barchowsky A.  Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.  J Clin Invest. 2008 Nov 13.  PMID: 19009047

  17. States JC, Srivastava S, Chen Y, Barchowsky A. Arsenic and Cardiovascular Disease. Toxicol Sci. 2008 Nov 17. PMID: 19015167

  18. Nemec AA, Leikauf G, Pitt BR, Wasserloos KJ, Barchowsky A.   Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells.  Am J Respir Cell Mol Biol. 2008 Dec 18.  PMID: 19097988

  19. Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD.  Surfactant Associated Protein B is Critical to Survival in Nickel-induced Injury in Mice.  Am J Respir Cell Mol Biol. 2009 Jan 8. PMID: 19131640

  20. Straub AC, LR Klei, DB Stolz, A Barchowsky.  Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. Am J Pathol 174, May 2009. PMID: 19349368

  21. Nemec AA, Barchowsky A. Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells. Toxicol Sci. 2009 Apr 29. PMID: 19403854

  22. Liu FJ, Barchowsky A, Opresko PL. The Werner Syndrome Protein Functions in Repair of Cr (VI)-induced Replication.  Associated DNA Damage. Toxicol Sci. 2009 Jun 1. [Epub ahead of print]  PMID: 19487340

Published Abstracts - past 5 years

      1. Barchowsky, A, LR Klei, DD Mayka, JC Davey, JW Hamilton and NV Soucy.  Chronic arsenic exposure enhances FGF-2 stimulated angiogenesis in vivo and tissue expression of angiogenic genes.  The Toxicologist 78 (S-1):170, 2004.

      2. O’Hara, KA, LR Klei, RJ Vaghjiani and A Barchowsky.  Selective signaling pathways for chromium(VI) induced patterns of transcription factor binding in exposed airway epithelial cells.  The Toxicologist 78 (S-1):239, 2004.

      3. O’Hara, KA, AA Nemec, J Alam, LR Klei, BT Mossman, and A Barchowsky.  Chromium (VI) inhibits heme oxygenase-1 induction in both cell and in vivo models.  Free Radic Biol Med. 37:S69, 2004. (Young Investigator Award).

      4. Klei, LR, N. Soucy, and A Barchowsky.  Differential oxidant-sensitive or -repressed vascular gene induction pathways stimulated by arsenic. Free Radic Biol Med. 37:S66, 2004.

      5. Klei LR, MA Ihnat, NV. Soucy, AA Nemec, A. Barchowsky. Differential effects of chronic low level arsenic exposures on transcription factor binding.  The Toxicologist 84 (S-1):238, 2005

      6. O’Hara, KA, RJ Vaghjiani, A A Nemec, LR Klei, A Barchowsky. Chromium(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck.  The Toxicologist 84 (S-1):232, 2005.

      7. Straub, AC, LR. Klei, NV Soucy, DB Stolz, A Barchowsky. Arsenic Stimulates Pro-Angiogenic Gene Expression and Changes in Vascular Architecture in the Liver. The Toxicologist 90 (S-1):91, 2006.

      8. Barchowsky A.  JNK activation by chromium in the lung.  The Toxicologist 90 (S-1):309, 2006.

      9. Nemec, A A, KA O’Hara, LR Klei, RJ Vaghjiani, A Barchowsky. Chromium(VI) requires histone deacetylase to induce interferon-stimulated genes. The Toxicologist 90 (S-1):309, 2006.

      10. Nemec, A, A, KA O’Hara, LR Klei, RJ Vaghjiani, A Barchowsky. Chromium(VI) induces genes through STAT1 transactivation of interferon-stimulated response elements.  The Toxicologist  96:224, 2007.

      11. Barchowsky, A., A.C. Straub, DB Stolz.  Arsenic-induced endothelial cell activation and vascular remodeling.  The Toxicologist 96:262, 2007.

      12. Straub, AC, DB Stolz, MA Ross, LR. Klei, A Barchowsky.  Arsenic stimulates hepatic capillarization and increases sinusoidal endothelial membrane bound Rac1-GTPase in vivo and ex vivo. The Toxicologist 96:306, 2007.

      13. Klei, LR and A Barchowsky. Synergies in vascular cell signaling stimulated by co-exposure to arsenic and ethanol.   The Toxicologist 96:306, 2007.

      14. Murray, AR, E Kisin, JP Fabisiak, JR Roberts, JM Antonini, C Kommineni, J Reynolds, A Barchowsky, V Castranova, V Kagan, and AA Shvedova. Combined exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. The Toxicologist 102:306, 2008.

      15. Nemec, A A, SA Sandel, GD Leikauf, BR Pitt, and A Barchowsky. Nickel induces metallothionein in airway epithelial cells by increasing intracellular zinc.  The Toxicologist 102:330, 2008.

      16. Straub, AC, DB Stolz, KA Clark, AG Chandura, and A Barchowsky.  Arsenic signals through NADPH oxidase to promote mouse liver sinusoidal endothelial cell defenestration and increased PECAM-1 expression.  The Toxicologist 102:333, 2008.

      17. Barchowsky, A, LR Klei, AC Straub, and D B Stolz. Signaling mechanisms for vascular responses to arsenic.  The Toxicologist 102:405, 2008.

      18. Klei, LR and A Barchowsky. Arsenic signals through a Gai-coupled pathway to induce angiogenic genes in human microvascular cells.   The Toxicologist 102:456, 2008.

      19. Nemec, AA and A Barchowsky Chromium silences nickel-induced vascular endothelial growth factor (VEGF) expression in human airway epithelial cells FASEB J. 22:764.3, 2008.

      20. Straub, AC, DB Stolz, KA Clark, and A Barchowsky. Arsenic signals through g-proteins and NADPH Oxidase (NOX) to promote mouse liver sinusoidal endothelial cell capillarization. FASEB J. 22:900.4, 2008.

      21. Klei, LR, AC Straub, DB Stolz, and A Barchowsky.  Arsenic requires sphingosine-1-phosphate type 1 receptors to stimulate vascular remodeling.  The Toxicologist 108: 43, 2009.

      22. Liu, F, A Barchowsky, and PL Opresko.  The Werner syndrome protein functions in repair of Cr(VI)-induced stalled DNA replication forks.  The Toxicologist 108: 220, 2009.

      23. Mann, KK, AM Padovani, WH Miller, AC Straub, and A Barchowsky.  Low dose arsenic potentiates a pro-atherogenic phenotype in macrophages and liver. The Toxicologist 108: 370, 2009.

      24. Nemec, A A and A Barchowsky. STAT1 is essential for chromium silencing of nickel-induced VEGF expression in human airway epithelial cells.  The Toxicologist 108:370, 2009.

      25. Barchowsky, A, LR Klei, AC Straub, DB Stolz.  Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. FASEB J. 23:116.10, 2009.

    Invited Reviews - past 5 years

    Prozialeck WC, Edwards JR, Nebert DW, Woods JM, Barchowsky A, Atchison WD. The vascular system as a target of metal toxicity. Toxicol Sci . 2008 Apr; 102 ( 2 ): 207-18 . Epub 2007 Oct 18. PMID: 17947343

    States JC, Srivastava S, Chen Y, Barchowsky A. Arsenic and Cardiovascular Disease. Toxicol Sci. 107:312-323, 2009. [Epub ahead of print] PMID: 19015167