COMMITTEE CHAIRPERSONS:

Dr. Julio Libman
Professor of Internal Medicine
Boulevard Orono 610-2 Piso
2000 Rosario
Santa Fe
Argentina

Telephone: 9011-54-41-257334
FAX: 9011-54-41-257334

Dr. Libman is currently investigating autoimmune and endocrine disorders.

Five most recent publications and/or presentations:

1. Fibrinogen in NIDDM, Revista de la ALAD, Vol. III, No. 2, 1995. Brazil.

2. Recent advances in the treatment of NIDDM. Boletin de la Sociedad Argentina de Medicina. No. 2 October 1995. Argentina.

3. Lipid profile in children and adolescents. Revista de Pediatria. Vol. XXIII, September, 1995. Argentina.

4. Body fat distribution, Metabolic Parameters and Vascular Complications in NIDDM. 15 IDF Congress, Kobe, November, 1994. Japan.

5. Lipid profile in newly diagnosed NIDDM. Revista de la SAD. Vol. 28, No. 4, 1994. Argentina.

Infectious, cancer, cardiovascular and endocrine disorders

Five most recent publications and/or presentations:

1. Detection and monitoring of HCV-RNA viremia using a competitive PCR and amplicorªHCV©monitor©response to interferon therapy and relationship to genotypes of hepatitis Cvirus.

2. Genotypes of Hepatitis C virus (HCV) in patients with HIV infection.

3. Viral load using amplicor-HIV-monitor and CD+ levels during protease inhibitor antiviraltherapy.

4. Identification of HCV genotype in blood banks. Dialysis unit's patients and high risk of viralexposure (IVDA).

5. Investigation of Apo B 100-3500 arg glumutation in Argentinian hypercholesterolemicpatients.

Five most recent publications and/or presentations:

1. Tormo A, Almiron M, Kolter R. Sur A, an Escherichia coli Gene Essential for Survival inStationary Phase. J Bacteriol 172(8):4339-4347, 1990

2. Almiron M, Link A, Furlong D, Kolter R. A novel DNA binding protein with regulatoryand protective roles in starved escherichia coli. Gene and Dev 6:2646-2654, 1992

3. Zambrano M, Siegele D, Almiron M, Tormo A, Kolter R. Microbial competition:Escherichia coli mutants that take over stationary phase cultures. Science 259:1757-1760,1993

4. Siegele D, Almiron M, Kolter R. Approaches to the study of survival and death instationary phase E.coli. In: S. Kjelleberg (ed). Starvation in Bacteria. Plenum Press, NewYork, 1993

5. Altuvia S, Almiron M, Huisman G, Kolter R, Storz G. The dps promoter is activated byOxyR during growth and by IHF and o5 in stationary phase. Mol Microbiol 13:265-272, 1994

Endocrine and psychiatric disorders

Four most recent publications and/or presentations:

1. Bol Acad Nac Med 71:571-582, 1994

2. Bol Programs Nacional Estadisticas de Salud. 1992

3. Medicina 48:365-370, 1988

4. Bulletin of Pan American Health Organization 13(4):354-364, 1979.

Dr. Bossio is currently investigating:

Infectious, genetic/hereditary and hematologic disorders. DNA typing

Five most recent publications and/or presentations:

1. Altmeyer RM, McNern JK, Bossio JC, Rosenshine I, Finlay BB, Galan JE. Microbiol 7:89-98, 1993

2. Kaniga K, Bossio JC, Galan JE. Microbiol 13(4):555-568, 1994

3. Bossio JC. Diagnostic applications of the polymerase chain reaction. Medicina 53(2):81-84,1993

4. "DEL DNA AL DNI" Primer Congreso Latinoamericano de Criminalistica y Criminologia July 1995 MISIONES. Argentina

5. "Genetica e Identidad: E1 ADN en la investigacion Judicial y policial" Instituto de CienciasPenales del Colegio de Abogados de Lomas de Zamora (Provincia de Buenos Aires, Argentina,November, 1995)

Dr. Distefano is currently investigating:

Congenital infection by cytomegalovirus, transplacental transmission of human CMV andpapillomaviruses

Five most recent publications and/or presentations:

1.

2. Teysie AR, Alonio VL, Distefano AL, Picconi MA. "Virologia" in: Virus Papilloma en laPareja Humana, p. 23-54. Eds Mural, Teysie, Baistrochi, Alfonsin. Editorial Ascune,1993

3. Teysie AR, Picconi MA, Distefano AL, Alonio LV, Eijan A, Pueyo S, Gorostidi and CasabeA. HPV DNA in Penile Carcinoma: A Retrospective Analysis de Primary and MetastaticLesions. 2nd International Congress Papillomavirus in human Patology. Book Summary p. 97,Paris April 6-8, 1994

4. Distefano AL, Picconi MA, Alonio LV, Dalbert D, Mural J, Bazan G, Garcia Carranca A,Teysie AR. Deteccion de virus papilloma humano por PCR©SSCP en lesiones de cervix pre ypost tratamiento con asa diatermica. Seccion 28 H13. VII Congreso Argentino de Microbiologia. Buenos Aires, 8-10 de Mayo de 1995

5. Distefano AL, Picconi MA, Ojeda E, Alonio VL, Dalbert D, Mural J, Bartt O, Bazan G andTeysie AR. Papilloma virus typing of penile lesions in sexual partners of women with genitallesions. Gynecopathology, 1996 (in press)

Dr. Frechtel is currently investigating:

Autoimmne, Genetic/Hereditary, Endocrine and Hematologic disorders.

Five most recent publications and/or presentations:

1. Frechtel A, Cardoso A, Llera A, Poskus E, Alonso A, Ruiz M. A case of allergy to humaninsulin associated with IgC/IgE ratio for specific antibodies. J Inv. Allerg and Cl Immunol 4(6),1994.

2. HLA v su relacion con la Diabetes Mellitus Insulinodependiente. Revista de la Asociacion Bioquimica Argentina 59:125-127, 1995.

3. Frechtel G, Varela V, Mainetti H, Marquez N, Targoynik H, Ruiz M. Tipificacion de HLADqB1 en diabetes insulinodependendiente. IX Congreso Argentino de Diabetes. 1994 SanMartin de los Andes, Neuquen, Argentina.

4. Frechtel G, Lopez A, Varela V, Mainetti H, Targoynik H, Ruiz M. Tipification de HLADQB en diabetes Insulinodependiente. 11 al 15 de Noveimbre de 1995. IX Congreso de laAsociacion Latinoamericana de Diabetes y X Congreso Brasilero de Diabetes, Brasil, page 78.

5. Frechtel G, Lopez A, Ruiz M, Targovnik H. Identificacion de mutaciones en el gen de laGlucokinasa en Diabetes Tiop MODY. 11 al 15 de Noveimbre de 1995, IX Congreso de laAsociacion Latinoamericana de Diabetes y X Congreso Brasilero de Diabetes, Brasil, Page 78, Libro de Resumenes

Dr. Libman is currently investigating metabolic and endocrine disorders including thyroid disease, IDDM diabetes and lipid disorders.

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Dra. Paula Padula
Instituto Carlos G. Malbran
Av. Velez Sarsfield 563
1281 Buenos Aires
Argentina

Telephone: 54-1-67-6117
FAX: 54-1-924-4062
E-mail: virus@malbra.sld.ar

Dra. Padula is currently investigating:

Infectious disorders

Five most recent publications and/or presentations:

1. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina(submitted).

2. Wild poliovirus surveillance: laboratory issues. Participation in this article of the PolioLaboratory network (submitted).

3. Relacion de las glicoproteinas estructurales del virus Junin con el gen de su precursor. VCongreso Argentino de Virologia.

4. Identificacion genetica de un nuevo hantavirus causante de sindrome pulmonar severo enArgentina. V Congreso Argentino de Virologia.

Dra. Maria Alejandra Picconi
Instituto Nacional de Microbiologia "Dr. Carlos Malbran"
Avda. Velez Sarsfield 563
1281 Buenos Aires
Argentina

Telephone: 54-1-3031806 & 3031811
FAX: 54-1-3031433 & 3032382
E-mail: virus@malbra.sld.ar

Dr. Picconi is currently investigating:

Viral oncogensis (Human Papilloma Virus (HPV), Epstein Barr Virus (EBV), Herpes Virus(HSV), Human T-Cell limphoma/leukemia Viruses (HTLV))

Five most recent publications and/or presentations:

1. Alonio LV, Picconi MA, Dalbert D, Mural J, Bartt O, Bazan G, Teyssie AR. Expressionof herpes simplex virus type 2 related proteins in cervical lesions and their relationship withpapillomaviruses infection. The Cervix & The Lower Female Genital Tract 8:331-337,1990

2. Picconi MA, Distefano AL, San Martino J, Cuello H, Mansilla L, Teyssie Ar. Human Papillomavirses in vulvar lesions. The Cervix & The Lower Female Genital Tract 11:29-31,1993

3. Teyssie A, Alonio L, Distefano A, Picconi MA. "Virologia" In: El Virus Papiloma en lapareja humana, J Mural, A. Teyssie, C. Baistrochi, A Alfonsin (eds) p. 23-54 Editorial Ascune

4. Teyssie A, Picconi MA, Distefano A, Alonio V, Eijan A, Pueyo S, Gorostidi S, Casabe A.HPV-DNA in penile carcinoma: a retrospective analyses of primary and metastatic lesions. Second International Congress of Papillomavirus in Human Pathology. Book of Abstracts p. 97. Paris, April 6-8, 1994

5. Distefano A, Picconi MA, Ojeda E, Alonio V, Dalbert D, Mural J, Bartt O, Bazan G,Teyssie A. Papillomavirus Typing of Penile Lesions in Sexual Partners of Women with GenitalLesions. Ginecopathology, 1996 (in press)

Diabetes: Genetics, autoimmunity and prevention

Five most recent publications and/or presentations:

1. "Early diabetes type I and type II. A South American approach". Houssay Memorial Lecture. XVth IDF Congress, November 1994. Kobe, Japan.

2. "Effects of high altitutde on glucose tolerance and insulin sensitivity in healthy subjects". XVth IDF Congress. Abstracts, page 209, poster presentation, November 1994, Kobe, Japan.

3. "Genetica de la DMID en Sud America". Lecture. IX Congreso de la Asociacion Latinoamericana de Diabetes. Foz do Iguazu. Brasil. November, 1995.

4. "Sindrome X vs. Sindrome Y". Lecture. Symposium on insulin-resistance. Sociedad Chilena de Endocrinologia. Santiago, Chile. April 1995.

5. "Historia natural evolutiva de al DMID: Una vision diferente". Lecture. Congreso Panamericano de Endocrinologia. Santiage, Chile. April 1994.