Human Cardiovascular Psychophysiology

Psychology 2560

Fall 2005 Syllabus

Photos of Students

Instructors	Contact Information
J. Richard Jennings	Office: E1329 Western Psychiatric Institute and Clinic Phone: 412-246-6210 Email: jenningsjr@upmc.edu
Peter J. Gianaros	Office: 433 Bellefield Towers Phone: 412-246-5970 Email: gianarospj@upmc.edu

Schedule	Meeting Locations
Lecture and Discussion: Tuesdays and Thursdays 3:00-3:50 pm	Western Psychiatric Institute and Clinic
Laboratory: Fridays 1:00-3:00 pm	- E1329 Western Psychiatric Institute and Clinic - 210 Bellefield Towers

Course Information

This course is designed to provide a basic competence in cardiovascular physiology and psychological influences on cardiovascular physiology. Cardiovascular pathophysiology will be discussed as a tool for understanding normal physiology as well as for its own sake. A lecture and proseminar approach will be used. The instructors will lecture on one topic per week, and the instructors and students will then discuss a primary reading on that topic. A laboratory session each week will also provide an introductory knowledge to a number of psychophysiological measurement techniques and data analytic approaches. Students are expected to complete the assigned readings before each lecture, discussion and laboratory session. For each discussion session, students will be required to email 3 questions concerning the reading to the instructors prior to the discussion session.

Grades will be based on midterm and final (nonculmulative) tests (70%), a student-led seminar at the end of the term (20%), and on class-participation and mastery of laboratory techniques (10%). For student-led seminars, each student will give a brief presentation on a topic of her or his choosing and will facilitate a discussion of an empirical paper related to that topic. Each student will also submit a brief paper related to her or his class presentation. This paper can be either a critique of the paper discussed in class or it can be a research proposal. The critique or proposal should be no longer than 5 pages. This paper is due on the day of the final exam.

The required text is Stress and Health: Biological and Psychological Interactions (2005, 2nd Edition) by W.R. Lovallo.

Date	Format	Topic	Reading	Location	Instructor
8/30	Lecture	Introduction	Lovallo, Ch 1	WPIC E1329	Jennings Gianaros
9/1	Lecture	Behavioral medicine	Lovallo, Ch 2 & 3	WPIC Lib Rm 1	Jennings Gianaros
9/2	Discussion	The cardiovascular reactivity hypothesis	Manuck et al. (1983). Behaviorally induced heart rate reactivity and atherosclerosis in cynomolgus monkeys. Psychosom Med, 45, 95-108.	WPIC E1329	Jennings Gianaros
9/6	Lecture	The stress response	Lovallo, Ch 5	WPIC Lib Rm 1	Jennings
9/8	Discussion	The cardiovascular reactivity hypothesis	Kamarck TW & Lovallo WR. (2003). Cardiovascular reactivity to psychological challenge: conceptual and measurement considerations. Psychosom Med 65(1): 9-21.	WPIC 474	Jennings
9/9	Laboratory	The electrocardiogram	Jennings et al (1981). Publication guidelines for heart rate studies in man. Psychophysiology, 18, 226-231. Dubin, D. (1979). Rapid interpretation of EKGs. Tampa, FL: Cover Press	WPIC E1329	Jennings
9/13	Lecture	Cardiac physiology	Rushmer, R.F. (1989). Structure and Function of the Cardiovascular System. In Schneiderman, S.M. Weiss, & P.G. Kaufmann (Eds.), Handbook of research methods in cardiovascular behavioral medicine, pp. 5-22. Plenum Press: New York	WPIC Lib Rm 1	Jennings
9/15	Lecture	Vascular physiology	Guyton, A.C., & Hall, J.E. (2000). Textbook of medical physiology (10th ed.), pp. 144-209. Supplementary Illustrations & Handouts from Burton, A.C. (1965). Physiology and biophysics of the circulation, Chicago: Yearbook Medical Publishers	WPIC Aud, 2nd floor	Jennings
9/16	Laboratory	Blood pressure	Shapiro et al. (1996). Blood pressure publication guidelines. Psychophysiology, 33, 1-12.	Bellefield Towers, Rm 210	Gianaros
9/20	Lecture	Homeostasis	Lovallo, Ch 4	WPIC Lib Rm 1	Gianaros
9/22	Discussion	Heart rate variability and cardiovascular risk	Steptoe et al. (2002). Stress responsivity and socioeconomic status: a mechanism for increased cardiovascular disease risk? Eur Heart J., 23, 1757-63.	474 WPIC	Gianaros
9/23	Laboratory	Respiration and heart rate variability	Berntson GG, et al. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34, 623-48. Stern et al. (2001). The respiratory system. Psychophysiological Recording, Oxford University Press.	Bellefield Towers, Rm. 210	Gianaros
9/27	Lecture	Central nervous system	Lovallo, Ch 6	WPIC Lib Rm 1	Gianaros
Sept 29	Discussion	fMRI	Gianaros et al. (2005). Is there a functional neural correlate of individual differences in cardiovascular reactivity? Psychosom Med, 67, 31-9.		Gianaros
9/30	Laboratory	fMRI	Chapters 1, 2, & 5 from Huettel et al. (2004), Functional Magnetic Resonance Imaging. Sinauer Associates; Sunderland, MA.	MR Research Center 8th Floor Presbyterian Hospital	Gianaros Davis
10/4	Lecture	Stress and endocrine function	Lovallo, Ch 7	WPIC Lib Rm 1	Jennings
10/6	Discussion		Gold et al. (1998) Corticotropin-releasing hormone gene expression by glucorticoids: Implication for understanding the staes of fear and anxiety and allostatic load Psychoneuroendocrinology,23, 219-243	WPIC 292	Jennings
10/7	Laboratory	Skin Conductance	Stern et al. (2001). Electrodermal activity. Psychophysiological Recording, Oxford University Press.	E1329, WPIC	Jennings
10/11	Lecture	Immune function	Lovallo, Ch. 8	WPIC Lib Rm 1	Jennings
10/13	Discussion		Cohen S. Doyle WJ. Turner RB. Alper CM. Skoner DP. Childhood socioeconomic status and host resistance to infectious illness in adulthood. Psychosomatic Medicine. 66(4):553-8, 2004. Redwine L. Snow S. Mills P. Irwin M. Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression. Psychosomatic Medicine. 65(4):598-603, 2003.	WPIC 474	Jennings
10/14	Laboratory	Strain gauge and photoplethysmography	Jennings et al. (1980). Noninvasive measurement of peripheral vascular activity. In J. Martin & P.H. Venables (Eds.), Techniques in psychophysiology, pp. 69-137. New York: Wiley	WPIC E1329	Jennings
10/18	EXAM			WPIC Lib Rm 1	Jennings
10/20	Lecture	Helplessness	Lovallo, Ch.9	WPIC 412	Jennings
10/21	Laboratory	Amplifiers, filters, resistors, etc.	Marshall-Goodell, et al (1990). Principles of bioelectrical measurement. In Cacioppo & L.G. Tassinary (Eds.), Principles of psychophysiology: Physical, social and inferential elements, pp. 113-148. Cambridge University Press: New York	WPIC E1329	Jennings
10/25	Discussion	Cognition and the cardiovascular system	Jennings & van der Molen (2005). Preparation for speeded action as a psychophysiological concept. Psychol Bull. 131, 434-59.	WPIC 292	Jennings
10/27	Lecture	Behavior genetics	Lovallo, Ch 10	WPIC 413A	Jennings
10/28	Laboratory	Impedance cardiography	Sherwood et al. (1990). Methodological guidelines for impedance cardiography. Psychophysiology, 27, 1-23.	WPIC E1329	Jennings
11/1	Discussion	Behavior genetics in cardiovascular health	Neumann, Serina A; Lawrence, Elizabeth C; Jennings, J. Richard; Ferrell, Robert E; Manuck, Stephen B. Heart Rate Variability Is Associated With Polymorphic Variation in the Choline Transporter Gene. Psychosomatic Medicine. 67(2) 2005, 168-171.	WPIC Lib Rm 1	Jennings
11/3	Lecture	Individual Differences	Lovallo, Ch 11	WPIC 474	Jennings
11/4	Laboratory	Ambulatory monitoring	Pickering, T.G. (1989). Ambulatory monitoring. In Schneiderman, S.M. Weiss, & P.G. Kaufmann (Eds.), Handbook of research methods in cardiovascular behavioral medicine, pp. 261-272. Plenum Press: New York. Chesney, M.A., & Ironson, G.H. (1989). Diaries in ambulatory monitoring. In Schneiderman, S.M. Weiss, & P.G. Kaufmann (Eds.), Handbook of research methods in cardiovascular behavioral medicine, pp. 317-331. Plenum Press: New York	WPIC E1329	Jennings Kamarck
11/8	Discussion	Psychosocial factors and CAD	Raikkonen, K; Matthews, Karen A; Sutton-Tyrrell, Kim; Kuller, Lewis H. Trait Anger and the Metabolic Syndrome Predict Progression of Carotid Atherosclerosis in Healthy Middle-Aged Women. Psychosomatic Medicine. Vol 66(6),2004, 903-908.	WPIC Lib Rm 1	Jennings
11/10	Lecture	Information Processing	Øhman , A. Hamm, A., & Hugdahl, K., Cognition and the autonomic nervous system. In J.T. Cacioppo, L.G. Tassinary, & G.G. Berntson (Eds.), Handbook of Psychophysiology (2nd ed.), pp. 533-575. Cambridge: New York. Jennings, J.R., & van der Molen, M.W. (2002). Cardiac timing and the central regulation of action. Psychological Research, 66, 337-349	WPIC 474	Jennings
11/11	Laboratory	Endocrine/Immune measures		GCRC	Muldoon
11/15	Discussion	Cardiac vagal control in health and disease	Jennings, JR; van der Molen, Maurits W; Somsen, Riek JM; Graham, Ralph; Gianaros, Peter J. Vagal function in health and disease: Studies in Pittsburgh. Physiology & Behavior. Vol 77(4-5)2002, 693-698.	WPIC Lib Rm 1	Jennings
11/17	Lecture	Lecture	Lovallo, Ch 12 Bradley, Moulder, & Lang, When Good Things Go Bad, Psychological Science, 16,468	WPIC 412	Jennings
11/18	Discussion	Design and statistics	Jennings, J.R., & Gianaros, P. (2006). Salient method, design, and analysis concerns. J.T. Cacioppo, L.G. Tassinary, & G.G. Berntson (Eds.), Handbook of Psychophysiology (3rd ed.), in press. Cambridge: New York	WPIC E1329	Jennings
11/22	Seminar		Hilary & Aric	WPIC Lib Rm 1	Jennings
11/ 24-25			Thanksgiving
11/ 29	Lecture and demonstration	The electrogastrogram and cross-organ inferences	Stern et al. (2000). The gastrointestinal system. In Cacioppo et al (eds). Handbook of Psychophysiology. Cambridge University Press.	WPIC Lib Rm 1	Gianaros
12/1	Discussion	Assessing autonomic reactivity to stress from other organ systems	Gianaros et al. (2001). Gastric myoelectrical and autonomic cardiac reactivity to laboratory stressors. Psychophysiology, 38, 642-52. Jennings & McKnight (1994). Inferring vagal tone from heart rate variability. Psychosom Med, 56, 194-6.	WPIC 474	Gianaros
12/2-9	Laboratory	Cardiology visits
12/6	Seminar		Jude & Liz	WPIC Lib Rm 1	Students
12/8	Seminar		Aimee & Kelly	WPIC 474	Students
12/13	Seminar		Betsy & Natalia	WPIC Lib Rm 1	Students
12/15	Seminar		Sarah & Catherine	WPIC 412	Students
12/16	EXAM			WPIC 292